Download Adrenal Toxicology by Philip W. Harvey, David J. Everett, Christopher J. Springall PDF

By Philip W. Harvey, David J. Everett, Christopher J. Springall

ISBN-10: 1420061291

ISBN-13: 9781420061291

Despite being considered as the commonest toxicological goal within the endocrine method, the adrenal gland has usually been missed in regulatory trying out. Adrenal Toxicology addresses the elevated curiosity in adrenocortical toxicology and the necessity for a source that makes thoughts to be had to envision adrenal endocrine disruption.

Examining present suggestions and the newest developments, Adrenal Toxicology studies the endocrinology, pharmacology, pathology and toxicology of the adrenal gland. this article offers details at the variety of gear and chemical substances that impact adrenocortical functionality and indicates standardized methods for in vivo and in vitro evaluation. This quantity additionally offers fresh advancements within the molecular mechanisms of toxicity to the adrenal cortex and medulla, and considers environmental adrenal endocrine disruption in sentinel species.

Adrenal Toxicology :

  • reflects the most important advancements remodeled the previous decade
  • focuses at the newest learn strategies, together with their makes use of and limitations
  • provides an built-in technique for adrenal toxicology evaluation
  • identifies wisdom and knowledge gaps, delivering impetus for regulatory consideration

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Extra resources for Adrenal Toxicology

Sample text

Lancet 1983; 1:1270. Leddingham IM, Finlay WEI, Watt I, et al. Etomidate and adrenocortical function. Lancet 1983; 1:1434. Lelli SM, Ceballos NR, Mazzetti MB, et al. Hexachlorobenzene as hormonal disruptorstudies about glucocorticoids: Their hepatic receptors, adrenal synthesis and plasma levels in relation to impaired gluconeogenesis. Biochem Pharmacol 2007; 73:873–879. Letcher RJ, Sanderson JT, Bokkers A, et al. Effects of bisphenol A-related diphenylalkanes on vitellogenin production in male carp (Cyprinus carpio) hepatocytes and aromatase (CYP19) activity in human H295R adrenocortical carcinoma cells.

Cytotoxic treatment of adrenocortical carcinoma. World J Surg 2001; 25:927–933. Akingbemi BT, Youker RT, Sottas CM, et al. Modulation of rat Leydig cell steroidogenic function by di-(9,2-ethylhexyl)phthalate. Biol Reprod 2001; 65:1252–1259. Albertson BD, Hill RB, Sprague KA, et al. Effects of the antiglucocorticoid RU486 on adrenal steroidogenic enzyme activity and steroidogenesis. Eur J Endocrinol 1994; 130:195–200. Andersen HR, Vingaard AM, Rasmusse TH, et al. Effects of currently used pesticides in assays for estrogenicity and aromatase activity in vitro.

As well as resulting from a loss of feedback inhibition of ACTH due to adrenocortical inhibition, adrenal hypertrophy may occur as a result of classical “stress” or pharmacological stimulation of the HPA axis, if these also cause persistent ACTH secretion. , 2007). Enlarged adrenal in the absence of clear evidence of adrenal functional competency should not in isolation be considered to be a “simple” stress-related effect (stress effects are considered to be of limited toxicological significance) and possible functional suppression should be investigated further.

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Adrenal Toxicology by Philip W. Harvey, David J. Everett, Christopher J. Springall

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