By Derek Leroith
Traditionally the sector of endocrine study has continuously been on the vanguard of clinical endeavors. The investigators of those very important breakthroughs in learn were rewarded by means of various Nobel awards. within the box of diabetes by myself, Nobel prizes were provided to researchers who came across insulin, characterised the protein and invented radioimmunoassays utilizing insulin as a paradigm. no longer unusually, biomedical researchers have constantly been attracted through the endocrine procedure and different comparable structures of intercellular conversation. over the last twenty years, endocrine study has constructed swiftly and tailored sleek molecular and mobile biology ideas for its particular use. those adjustments have allowed researchers within the box to keep up their part. hence, endocrine disease-related genes were characterised and mutations in those genes have helped clarify universal and much less universal endocrine issues. Our figuring out of the legislation of gene expression has been tremendously more desirable by means of molecular recommendations. In an try and deliver investigators brand new with the hot advances during this exploding box we have now made up our minds to post a sequence entitled Advances in Molecular and mobile Endocrinology. the world over recognized investigators have agreed to take part and their contributions are preferred. quantity 1 has serious about points of the hypothalamic-pituitary axis together with GnRH and GH gene law, molecular points of insulin, insulin-like progress elements and glucagon. furthermore, stories at the lately cloned calcium receptor and steroid receptor interactions with DNA are provided.
Read Online or Download Advances in Molecular and Cellular Endocrinology, Vol. 1 PDF
Best endocrinology books
Until eventually lately, the renin-angiotensin-aldosterone approach has been thought of a systemic endocrine hormonal method completely. it's referred to now that every element of the renin-angiotensin process is produced, synthesized and certainly, found in many organisms together with the center and vessels. This quantity offers the newest scientific and laboratory reports of the best physicians and investigators within the box of the neighborhood cardiac renin-angiotensin aldosterone process.
It is a designated compilation, via specialists all over the world, addressing how diabetes affects the anxious process. for instance, diabetic polyneuropathy, a ailment extra universal than MS, Parkinson’s disorder, and ALS mixed, is an immense resource of incapacity to diabetic people all over the world. This publication addresses diabetic polyneuropathy and the way diabetes alters different elements of the apprehensive method.
Additional info for Advances in Molecular and Cellular Endocrinology, Vol. 1
USA 88, 11124-11128. J. (1992). Calcium signaling and episodic secretion of gonadotropin-releasing hormone in hypothalamic neurons. Proc. Natl. Acad. Sci. USA 89, 8462-8466. J. (1993). Expression of gonadotropin-releasing hormone receptors and autocrine regulation of neuropeptide release in immortalized hypothalamic neurons. Proc. Natl. Acad. Sci. USA 90, 3908-3912. L. (1994). Hypothalamus-specific regulation of gonadotropin-releasing hormone gene expression. Recent Prog. Hormone Res. 50, 459-463.
L. (1993). Transcriptional and post-transcriptional regulation of gonadotropin releasing hormone gene expression by the activation of protein kinase C pathway in a mouse hypothalamic GT1 cell line. Soc. Neurosci. ). L. (1994). Second messenger regulation of mouse gonadotropin-releasing hormone gene expression in immortalized mouse hypothalamic GTI-3 cells. Mol. Cell. Endocrinol. 102, 85-92. Chapter 2 MOLECULAR ASPECTS OF HORMONE DEFICIENCY CAUSED BY PIT-1 GENE MUTATIONS LAURIE E. COHEN, SALLY RADOVICK, and FREDRIC E.
Acad. Sci. USA 90, 3908-3912. L. (1994). Hypothalamus-specific regulation of gonadotropin-releasing hormone gene expression. Recent Prog. Hormone Res. 50, 459-463. L. (1996). GATA-binding proteins are essential for activity of the gonadotropin-releasing hormone neuron-specific enhancer. Mol. Cell. Biol. 16, 3596-3605. , & Negro-Vilar, A. (1991). Morphological characterization of immortalized hypothalamic neurons synthesizing luteinizing hormone-releasing hormone. Endocrinology 129, 1575-1583. A.
Advances in Molecular and Cellular Endocrinology, Vol. 1 by Derek Leroith