By T. Scott Stroup, Jeffrey A. Lieberman
Antipsychotic drugs are a key remedy for schizophrenia and revenues of antipsychotic medications method $20 billion in line with 12 months, with fierce advertising among the makers of the medicine. The U.S. nationwide Institute of psychological health and wellbeing subsidized the medical Antipsychotic Trials of Intervention Effectiveness (CATIE) venture to supply self sufficient information regarding the comparative effectiveness of medicines. CATIE was once the biggest, longest and so much entire examine of schizophrenia thus far. carried out below rigorous double-blind stipulations, Antipsychotic Trials in Schizophrenia provides the definitive archival result of this landmark examine. The middle of the publication includes chapters considering particular results that set the CATIE findings in a much broader context. additionally incorporated are chapters at the layout, statistical analyses and implications for researchers, clinicians and coverage makers. Psychiatrists, psychiatric researchers, psychological future health coverage makers and people operating in pharmaceutical businesses will all locate this to be crucial interpreting.
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Extra info for Antipsychotic trials in schizophrenia : the CATIE project
Analysis at fixed time points Some assessments, such as neurocognition, quality of life, and laboratory parameters were measured infrequently. For example, neurocognition was assessed at months 2, 6, and 18; quality of life was measured at 6, 12, and 18. For these parameters, we decided that repeated measures analysis was better as a secondary or supportive analysis, due to the small number of assessments, long duration between them, and substantial phase discontinuation over time. Instead, one of the time points was selected a priori as the primary time point, and the others were considered secondary.
For example, neurocognition was assessed at months 2, 6, and 18; quality of life was measured at 6, 12, and 18. For these parameters, we decided that repeated measures analysis was better as a secondary or supportive analysis, due to the small number of assessments, long duration between them, and substantial phase discontinuation over time. Instead, one of the time points was selected a priori as the primary time point, and the others were considered secondary. Separate treatment group comparisons were conducted at each time.
The interview also included questions about the positive aspects of caregiving and positive contributions of patients to family functioning. Medication adherence Medication adherence was measured at each monthly visit using pill counts. In addition, at each visit study personnel synthesized information from the pill count and any other relevant information into a Global Judgment of Medication Adherence. 4). Substance use Substance use was examined in multiple ways. Subjects were asked quarterly about drug and alcohol use.
Antipsychotic trials in schizophrenia : the CATIE project by T. Scott Stroup, Jeffrey A. Lieberman